If you are looking to get the best indoor comfort you are going to have to make a major investment.
Sure if you have what you think is the best indoor comfort with a good central heating and air conditioning system and portable air purifiers is fine. However you are going to need to make a major investment into a whole home air purification system if you want the very best in indoor comfort. A whole home air purification system goes into your central heating and air conditioning system and provides you with the very best indoor air cleaner you can imagine all while running your heating as well as your air conditioning at the same time. The air purification from the whole home air purifier comes out of the same exact air vents from your heating and air conditioning system. And the whole home air purifier is controlled on the same exact thermostat in which you set the temperatures for your central heating and air conditioning system unit on. I personally did invest into a whole home air purification system because I wanted to have the best indoor comfort possible in my home all together. And I am so glad I did because I have never felt so great until I got myself one of those whole home air purification systems. They are the best things really. It is just too bad that they are so darn expensive and take a bank loan to get unless you are a rich person!