If you are looking to get the best indoor comfort you are going to have to make a major investment.
Sure if you have what you suppose is the best indoor comfort with a nice central heating, ventilation, & A/C & portable air cleaners is fine.
However you are going to need to make a major investment into a whole apartment air cleaner if you want the legitimately best in indoor comfort. A whole apartment air cleaner goes into your central heating, ventilation, & A/C & provides you with the legitimately best indoor air cleaner you can imagine all while running your heating and your air conditioning at the same time. The air purification from the whole apartment air cleaner comes out of the same exact air vents from your heating, ventilation, & A/C. And the whole apartment air cleaner is controlled on the same exact control component in which you set the temperatures for your central heating, ventilation, & A/C component on. I personally did invest into a whole apartment air cleaner because I wanted to have the best indoor comfort possible in my apartment all together. And I am so cheerful I did because I have never felt so good until I got myself one of those whole apartment air cleaners. They are the best things really. It is just too bad that they are so darn extravagant & take a bank loan to get unless you are a rich person!